Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded form.
Prions are self-propagating proteins involved in transmissible spongiform encephalopaties in mammals.An aberrant conformation with amyloid-like features of a cell surface protein, termed prion protein (PrP), is thought to be the essential component of the infectious particle, though accessory co-factor molecules such as lipids and nucleotides may b